99Science · AI & science

SCIENCE UNDER AUTOMATION

AI in Clinical medicine: capabilities and evidence

Clinical work connects diagnosis to treatment, follow-up and responses to complications in real patients.

Autonomy · up to 4.4 / 10

Model interval: 2.1–4.4. Assessed 21 October 2026.

Two equally weighted workflow families: a bounded operational task and an investigation or deployment beyond that task. Inherited subfields use this parent scenario.

Calculation and work mix

Each requirement uses the operational scale from 0 (independent execution unestablished) to 4 (reliable independent execution in the stated setting). A workflow takes its lowest requirement level. The two workflows receive equal weight; the headline is 1 + 9 × weighted level / 4.

These levels are source-linked model assignments, not measurements reported by the papers. “Up to” is the upper model bound, not a probability or a forecast date.

Assess a patient and recommend management: 1–2 / 4.

Deliver treatment and manage an evolving clinical course: 0–1 / 4.

Upper bound with 75:25 workflow weights: 4.9. With 25:75 weights: 3.8.

What has AI demonstrated?

An agentic AMIE system was compared with 21 primary-care physicians across 100 simulated multivisit cases and was non-inferior on specialist-rated management reasoning.

Test
Peer-reviewed randomized blinded virtual clinical evaluation
Comparison
Comparators vary by study; see the linked sources.
System and version
AMIE disease management · 2026-06-17
Evidence checked
2026-10-21

Virtual consultations and medication questions do not test treatment delivery, physical examination or longitudinal outcomes in patients.

What does the field require?

Assess a patient and recommend management

Deliver treatment and manage an evolving clinical course

Research tasks

Assess a patient and recommend management

See the requirement-level assessment and its sources.

Deliver treatment and manage an evolving clinical course

See the requirement-level assessment and its sources.

Can AI replace the whole workflow?

The results above measure specific tasks. The field assessment also requires completion of the connected workflow, including the requirements listed here. A field-wide replacement percentage has not been established.

Read the assessment method

Sources and related evidence

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