SCIENCE UNDER AUTOMATION
Experiment-guided AlphaFold3
Experimental guidance improves agreement with measured conformational ensembles.
What this result supports
Unguided predictions do not reliably recover experimental conformational distributions; static folds are a narrower endpoint.
Evidence record: peer_reviewed. Checked: 2026-10-20.
Where this evidence is used
Structural biology
- Resolve conformations and interactions: Ensemble work uses experimental constraints.
- Obtain discriminating measurements: Autonomous experimental acquisition is not tested in these sources.
- Validate a mechanistic explanation: Whole mechanistic research is not evaluated.