SCIENCE UNDER AUTOMATION
MULTICOM / CASP16
Top-1 correct folds for 82/84 evaluated domains; near-native TM-score >0.9 for 62/84.
What this result supports
84 domain units from 58 targets are not independent proteins. Additional sampling and ranking differs from stock AlphaFold3; no full-field claim.
Evidence record: peer_reviewed. Checked: 2026-10-20.
Where this evidence is used
Structural biology
- Prepare sequence and alignment inputs: MULTICOM includes engineered alignment and sampling choices.
- Predict and rank a fold: Blind CASP16 demonstrates strong tertiary structure prediction.
- Determine whether the prediction is adequate: Structural similarity and confidence do not establish experimental validity.